There are markings on the manifest indicating that Isabella & her 3 daughters were naturalized. There is more information on manifest markings here: http://www.jewishgen.org/infofiles/manifests/
I found an entry on a naturalization index for an Isabella Reguin (Linford) from Great Britain. She was living at 2 1/2 S. Third Ave., Taftville, Connecticut and was naturalized in New London Co. Court on 10 Nov. 1936.
There is an entry on the Social Security Death index for Isabella L. Reguin, born 8 Dec 1908, died 9 Jan 2003, and last residence of Norwich, Connecticut. Seems like it might match the daughter.
I found an obituary for a Theresa (Reguin) Meskiewicz of Norwich, born in Taftville, CT on 4 Oct. 1938 to Paul & Isabella Reguin. Perhaps she was named after Isabella's sister.