Thanks everyone for your replies.
Wexflyer: I hope this isn’t too much information for you. In terms of addresses, John Brennan was living at "139 Shannon," and his bride Margaret Brown was living at "100 Shannon." From Griffiths I take it that these were on the east side of the River Slaney. Griffiths shows a couple hundred homes/shops in "The Shannon," and a much lesser number in "Shannon Hill." I am assuming that the two “Shannon” addresses were in Shannon Hill. Based on the map in Griffiths, I also think that Shannon Hill is just across the bridge, and maybe up-slope of "The Shannon" -- which itself looks like residences/shops along the low road to Drumgold. Does that sound right?(if you know Enniscorthy)
As for occupations, John Brennan was a laborer, and his father Thomas was a weaver; the father of the bride, Thomas Brown, was a laborer as well. I understand that there was a lot of home-based weaving in Ireland in the 1800's (wool, linen), but based on what I have read I would have thought it had faded away by 1865 especially in the southeast, displaced by the industrial operations of that era. As for the laborers in 1865, there was probably plenty of work at the Quay, where John Brennan actually moved with his new wife in 1866 (per civil record).
Other than that, I have no other information on either Thomas (Brennan, Brown), and they don't appear in Griffiths for the CP's on either side of the river (St Mary’s, Templeshannon). There are Thomas Brennan’s in Monart and Ferns CP's, so I might look some more in those two areas which are nearby Enniscorthy. There is a widow Brown living on The Shannon (in Griffiths) – I am assuming that she is new bride Margaret’s mother, for now.
Aghadowey: yes I have all of that information, although it took me months to find out all of the info you sent me after just hours after my post! I have done pretty exhaustive research in the US, and I am turning my attention to Wexford now. Once the church records are posted by NLI in July, I hope to find out more. Also, I will try to get access to the 1861 Census fragments for Enniscorthy – any advice on that?
I will be visiting Enniscorthy this summer and am trying to get good sense of the layout and history, and take some pictures of “Shannon” and “The Quay,” even though they have certainly changed a good deal since 1860.
Healyj: I have been assuming that my Brennan’s migrated over to Wexford and Enniscorthy, given the large concentration of Brennan’s in Kilkenny, especially Idough. I figure that this started to happen after the upheaval and land confiscations of the 1600’s and afterwards. Do you have any information on that?
Thanks again everyone, your help is much appreciated