Hi Neil, welcome to Rootschat. I'm not related but found the following:
Birth registrations:
Margaret Ann dau. of Samuel Higgins & Sarah Jones - Holyhead - 17 May 1857
Thomas son of Samuel Higgins & Sarah Jones - Holyhead - 6 Apr 1859
William James son of Samuel Higgins & Sarah Jones - Holyhead - 15 Aug 1861
James Condren son of Samuel Higgins & Sarah Jones - Holyhead - 16 Sep 1863
George Samuel son of Samuel Higgins & Sarah Jones - Holyhead - 13 Oct 1865
Samuel George son of Samuel Wilson Higgins & Sarah Jones - Holyhead - 24 May 1867
Sarah Eliza dau. of Samuel Higgins & Sarah Jones - Holyhead - 11 Jun 1869
Annie Frances Letitia dau. of Samuel Higgins & Sarah Jones - Holyhead - 29 Oct 1875
Benjamin John Havelock Skobeloffe son of Samuel Wilson Higgins & Sarah Jones - Holyhead - 23 Jan 1878
Charlotte Alice and Mary Hannah weren't found.
Death registrations:
George Samuel Higgins, age 4 months, 21 Feb 1866 at Albert Place, Holyhead, son of engine driver Samuel Higgins. Informant Alice Jones, Albert Place, Holyhead.
Samuel Wilson Higgins, 67, 30 Mar 1901, Glan y Don, Holyhead - railway engine driver. Informant Benjamin Higgins, son, same address.
Sarah Higgins, 74, 15 Sep 1916, Station St, Holyhead, widow of railway engine driver Samuel Higgins. Informant J Higgins, son, London Rd, Holyhead.
Marriage:
Samuel Higgins and Sarah Jones did not marry on Anglesey. FreeBMD has a possible marriage - AMJ 1856, Liverpool 8b 254.
A number of their children were married on Anglesey and I will post details if you do not have them.
Hope this helps.