On the 1901 census my g.grandfather a butcher with his own shop was living with his 3rd wife and his 5 children from that and his previous 2 marriages. In August 1902 he was found wandering and, originally, it was thought he was a labourer, he was found to be a tall, well nourished but demented man. Apparently, he'd had a previous attack some 8 years previously which would have been between his 2nd and 3rd marriage. So he married his 3rd wife whilst already infected but it must have been dormant then as he had 3 perfectly healthy children with his 3rd wife.
It all seems very sad to me, his first wife dies after only 20 months of marriage leaving him with a baby to look after, yet he doesn't marry for another 10 years. That wife died 4 years later (from delerium tremens so not a very good wife) and left him with another 2 children to look after. At some stage after that wife's death he left Manchester (leaving his 3 children with his mother) and went to Yorkshire where the family originally came from. It seems it was in Yorkshire that he became infected, but it was also where he met his 3rd wife. She was 41 but still managed to give him 3 more children, but just as he must have thought he was settled, his past came back to haunt him and kill him.