In 1901 I think Edward is at 9 Caithness Street, Milton, Glasgow (Ancestry)
Edward McDonald age 38, occ Causewayer, born Ireland
Margaret McDonald age 25, wife born Glasgow
Mary Ann McDonald, daughter age 5 born Glasgow
Susan McDonald, daughter age 4 born Glasgow
Ellen McDonald, daughter, age 2 born Glasgow
Margaret McDonald, daughter age 6months born Glasgow
A hint on Ancestry suggests that wife Margaret was nee Boyle and there is a marriage on Scotlandspeople in Milton in 1895 between an Edward McDonald and a Margaret Boyle.
Using the index to 1911 census on Scotlandspeople the family seem to be in Paisley in 1911. Margaret (born 1900) is not with them but other names tally. Ref is 573/1 61/5
Edward age 46
Margaret age 32
Mary Ann age 15
Susanagh age 14
Ellen age 12
Jane age 8 ( this could be the sister Jean that Margaret went to in US)
Elizabeth age 6
Edward age 5
Francis age 3
James age 0
Suggestion on Ancestry that Susan married Francis J Carey and they settled in New York ( there is a possible marriage in Milton in 1922). In 1930 US census Susan's brother Edward McDonald ( b 1906) is shown as living with them.
Can't see anything on Edward prior to 1901 and he looks to have been born just prior to the start of statutory birth registration in Ireland in 1864. If the 1895 marriage is correct then it will give parents, names for both Edward and Margaret and might help you move further back ( at least with Margaret, who seems to have been born in Scotland).
Isobel