I can't believe how long I've spent on this family!
I decided to create a summary for Eli's profile, which I will reproduce below. I think that it contains most of the important points, and at this point I will leave it for now, unless someone happens to be able to shed light on the death of Mary (first wife), anything about 2nd wife Ann, or anything further about the youngest offspring I could get to.
The burial card I refer to is something I stumbled across serendipitously, after going to the Glenwood Cemetery website. It turns out that all of their interment cards are (supposedly) online - although as I found, some of those mentioned on Eli's card don't have their own records for some uknown reason. (I did just shoot them an email in case they have anything else to help.)
https://www.familysearch.org/ark:/61903/3:1:3QS7-99D6-N9ND-J?i=2070&cc=2170640&cat=2170640 - showing a "Mary A." - so perhaps she was Mary Ann?
So here goes, the summary:
Eli (b. Newick 1827) emigrates to America with wife Mary (birth unk.).
One of their daughters, Emily, is born in England (1856-7, but cannot pinpoint a likely birth record in GRO - nothing there in Lewes dist.), the other, Ellen/Eleanor, in Rochester, NY (Aug 1858 - no birth record).
Emily disappears off the radar after 1871, when she is recorded as aged 14 upon re-entry to the US at NY.
Eleanor (probably) has a child out of wedlock aged 18 in 1877, Bertha (later Smith), marries first James. A. Clark, who is a wastrel, divorces him and marries Frank A. Clark (not known if related). She has a son with Frank, Leonard Clark, who marries Katherine Martie and has a daughter, Elizabeth.
Bertha Smith is shown as daughter of Eli and Ann in one of the 1880 Census records, but grand-daughter (b.c. 1877, mother born NY, father Virginia) in 1900. It looks as if Eli and Ann (?) raise Bertha.
No death records are found for Mary, nor any other records for this second wife Ann(ie).
Bertha marries (? no record found) and has a son, Laurence N. Smith. (His only record is on the 1900 Census, with grandfather Eli and mother Bertha.) She dies young (25) of tuberculosis.
Eli remarries Lucy Bryant in 1886 but is widowed by 1900. [The 1890 Census records were apparently mostly destroyed by fire - nothing for this family remains available.]
In 1887 Eli and Eleanor are running a successful variety store, when Eleanor's husband James Clark shoots Eli in the abdomen. He is not expected to live, but pulls through.
At this point (Mar 2018), no further offspring have been found (of g-grandchild Elizabeth, or grandchild Laurence) - but not completely ruled out yet either.
Eli's burial plot, at the time of his death in 1904, also accommodated Bertha, Frank Clark (Eleanor's 2nd/3rd husband), Mary A. Hart (but no card is found for her, and no other details of death), George Clark(infant death? - nothing found), and a William T. Bryant (child of Eli's 3rd wife Lucy? - nothing found). Eleanor is later buried with Frank.
Edit: I forgot to add that one other loose end is that Eleanor's marriage to Frank in Virginia in 1886 (aged 30) shows her as a widow:
https://familysearch.org/ark:/61903/1:1:XR7W-S6Y. And Bertha's later census record does show her as father born Virginia, but I haven't established whether there's a link there, or just coincidence. Perhaps Eleanor spent some time in Virginia.
Can't recall all whether previously shown on this thread, but there are also memorials on Findagrave for "Elnora", Frank, Eli and Bertha.
(Oops, just removed a note I made about possible burial for Emily, because it was in 1870, and there's a record for her with the family returning via NY in 1871!)