I am getting confused now, so is it John, baptised 11 November 1831 in Canonbie and Jane, baptised 24 November 1833, children of John Murray and Jane Wylie, that you are looking for, and if not, whom are you looking for, and when and where were they born?
If you know them, please, please always state people's dates, even if only the year. Also, if you start other threads about the same people, please put a link to each of those threads, especially when you then ask people to look at them, so that they are easy to find.
akc found them for you 9 years ago in the 1841 census in Langholm with their father and stepmother. I gather that you have not found them in any later census or in marriage or death records.
It may be that the reason no-one has found them is that there is nothing to find. Or that there are just too many to check, both names being very common. There are, for instance, after eliminating the ones whose mothers' maiden surnames are listed in the index, 62 deaths of John Murrays born 1831 plus or minus one year, and 70 deaths of Jane Murrays and 6 deaths of Jean Murrays born 1833 plus or minus one year. The only practical way to check all those would be to go to a Scotland's People Centre for a day. Otherwise it would cost you up to £153 to check them all online, with no guarantee that you would find them.
I take it that you have considered the possibility that one or both died or emigrated?
There is an unmarried 18-year-old Jane Murray, born Dumfries-shire, a servant in the household of Jane Tinning in Dumfries in 1851. The transcription doesn't say in which parish she was born, but you could take a look at the original and see if it says that she was born in Canonbie.
There are two John Murrays aged 49 plus or minus 4 years and born in Canonbie in the 1881 census; one aged 45 in Hawick and one aged 47 in Canonbie. Have you definitely eliminated both of those?