Hello
Sorry not to check in for a few days but I've been away.
So let's start with that marriage in 1810 at St Marylebone 11.6.1810
John Clayton and Elizabeth Webber bach and spinster both of this parish
He signs and she makes her mark.
witnesses John Defoe? and mark of ? Pickering.
And that's were I see the problem because they do seem to disappear.
No sign of them having children

possible burial John Clayton 1.5.1831 at Uxbridge age 44 but that clashes with the 1851 census which gives the place of birth for him.But relooking at the 1851 census they are back in Lincolnshire which is unlikely.
Ciderdrinker