In 1861 246/118/20
Thomas is 31 yrs p, b Bethnal Green and Mary A is 41 yrs. She is born Bishopsgate.
This looks quite good
Mary Ann Sadler born 12th December 1839 and baptised 15th January 1840
Parents Thomas Sadler and Ruth Sadler (Maslin) address 9 North Place, Kingsland Road
Thomas is a Chemist

The baptism is Non-conformist, Bishopsgate.
You could try to follow that up to check.