I have the marriage for Geo. Pickup and Alice Maden and, as you say, there are a number of other marriages between a Geo. Pickup and an Alice in the Bury area as well as Haslingden. I thought the G & A living at Top of the Lee might have been the grandparents of the Sarah Pickup I'm trying to untangle however, it looks as though they were her parents and my confusion is with Bank Lane, Top of the Lee and Shuttleworth as geographic locations.
Are Bank Lane and Top of the Lee two separate abodes/addresses? Initially, I had Sarah Pickup b. abt 1830, Shuttleworth, with no mention of Bank Lane until I noticed several public member trees on Ancestry with varying birth dates between 1831 and 1833, Top of the Lee Farm, Shuttleworth Lane.
Top O' th' Lea is definitely a farm which still exists, proof being the photographs. Whether there was more than 1 farm or cottages 200 years ago, I don't know. You need to look at old maps, including the tithe map. The oldest Ordnance Survey map and the tithe map are from around 1840. Tithe maps & records showed names of occupiers and owners of each portion of land. Ramsbottom Heritage Society produced a "Date of Build Register" for buildings within the former Ramsbottom Urban District Council area. Information was collected from datestones and census and other records. A new edition was made either this year or last and put on the society website. It's a large document.
Bank Lane is an area in Shuttleworth. It's at the south side of the village of Shuttleworth. Top O' th' Lea farm is about half-a-mile NE of Bank Lane. Between Bank Lane and Top o' th' Lea farm are a stream called Cross Bank Brook, and Bamford Road. (I don't know if Bamford Rd. existed when George Pickup lived in the area.) Turn Rd. (a short road) leads off Bamford Rd. to Bury Old Rd. Half-a-mile south of Bank Lane is an area called Fletcher Bank.
Shuttleworth is a very small village and was part of the township of Walmersley-cum-Shuttleworth. A township was a division of a civil parish. Civil parishes and townships were administrative areas for things like poor relief. A township wasn't the same as a town. Walmersley-cum-Shuttleworth township consisted of some small villages or hamlets, farms, cottages, mills and quarries when George Pickup's children were born. The last councillor for Shuttleworth ward on Ramsbottom District Council represented an electorate of around 300 in 1972. He's in the House of Lords now. (From small beginnings ...)
If all those children with parents George & Alice who were baptised at Holcombe and Edenfield were children of the same couple, I think that sometimes a specific abode was written in the register and sometimes only an area.
I may have located another farm, Moorside, Shuttleworth, abode at baptism of James at Holcombe in 1818. The present Moor Side Farm is on Moorside Lane, between Bamford Rd. and Rochdale Rd.
Another abode was Glorybutts (baptism of Betty, 1807 at Holcombe). That's one I can't place. I think it was an area in the Walmersley part of Walmersley-cum-Shuttleworth. It was abode for some families in Christ Church, Walmersley registers. Abode for baptism of Alice 1809, next child George & Alice Pickup was Walmersley.
George's occupation wasn't stated at the first 3 baptisms at Holcombe (John 1805, Betty 1807, Alice 1809). Occupation was husbandman for Anne's baptism at Edenfield 1812. Occupation farmer from 1815 (Abraham's baptism).
Another Pickup burial. Edenfield Chapel 21st Dec. 1810, Robert Pickup age 31, abode Top of Lee.
John & Jane Pickup lived at Bank Lane. They had son George baptised 1830. A George Pickup aged 3, of Bank Lane, was buried 1833. (John was name of a son of George & Alice, baptised 1805 at Holcombe.)
Burial Emmanuel, Holcombe 1851
Alice, age 72, widow, spouse of George, abode Heywood, formerly Top of the Lee, Shuttleworth
If Alice's age at death was correct it would make her over 50 when the last child was born. Age at death was sometimes estimated.
Have you found Alice and children in 1841 and 1851 censuses? What was Alice's place of birth on 1851 census?
Census enumerator's books included a description of the enumeration area, naming boundary roads, rivers or other landmarks. Browsing pages is useful for familiarising yourself with the area.