I think I've very occasionally spotted a fairly distinctive mark (perhaps based on an initial?) where you might be able to speculate on it being the same person, but where it's just a cross I think it's more or less impossible.
In fact to my eye, these crosses don't look particularly similar. The cross is usually more of an x than a +, and if you look at these as x's, the first one has the heavier stroke going from top left to bottom right, while the second one goes from top right to bottom left - it's tempting to think that one is by a left-hander and one by a right-hander. The first one also looks shakier.
However, there are many other factors involved: shape of nib, position (rotation and tilt) of book, sitting or standing, how much elbow room, whether the person needed to make his mark once a week or less than once a year (to give an idea of how consistent his marks might be), whether he'd hurt his hand etc etc. If you can answer all of those you might be able to do a fair comparison, but if you can't I'm afraid it's only ever going to be guesswork.