There are two major approaches to genetic genealogy testing:
1) atDNA (autosomal) testing. This is a very economical test (around $100) that can find matches for all of your ancestral lines which is a huge advantage. It is an excellent test if you have a lot of recent brick walls (after 1800), recent adoptions where genealogical records are very challenging to break through brick walls or if you interested in finding matches to add to your growing family history.
However, the early entry price can be misleading as those who really get into this testing, test their closer relatives to determine which atDNA segments belong to which ancestor. So many atDNA testers end testing several times. Another disadvantage is that the atDNA is recombinational DNA where 50 % of your DNA is inherited from each parent. By the time you reach the early 1800s, many of your segments are so small that can no longer reliably detect some of your ancestors, so if you have brick walls in the 1700s, YDNA may be a better option.
2) YDNA has a tremendous promise that will eventually be able to assign mutations to all of male ancestors on our pedigree charts. We are only five or ten years away from this type of discovery. There are already a few that have actually assigned a unique combination of YDNA mutations to specific individuals on their pedigree chart. If you have two or three brick walls that are your main interest - YDNA testing is the way to go. I now have two YSNP branches that are only for my particular line of Caseys and several YSTR branches below these YSNPs that chart my Casey cousins. I have the genealogical challenge of having 50 known male adults living in western South Carolina in 1800 where traditional genealogical records have failed to connect to date.
The downside to YDNA testing, you really can only afford the cost AND time to research two lines maybe three or four. YDNA testing is much more expensive but yields more information for breaking through your brick walls. I was the first to order the Next Generation Sequencing test under R-L226 which has Dal Cais origins. I ordered the YElite 1.0 test from Full Genomes Corporation 18 months before FTDNA delivered their results of their first Big Y test. This test was $1,400 at the time, but this test was the first test that later revealed seven branches under L226. The most recent two branches are for my particular Dal Cais Casey line.
But the progress of expanding L226 from only the L226 YSNP two years to 44 branches has been costly. A whopping $36,000 on sixty Big Y tests and five Full Genomes tests. Another $10,000 has been spent on L226 SNP packs and another $3,000 on individual YSNP tests. This is only YSNP testing costs and YSTR testing another $200,000 on top of that.
But look what this aggressive testing has yielded:
1) 44 branches under L226 (second largest Irish haplogroup), 520 testers at 67 marker tests where around 40 surname clusters have been identified (including six different O'Brien clusters and three different Casey clusters).
2) We are now able to chart 80 % of the 520 testers under L226 with accuracy between 60 and 95 % with an average around 75 %. That is over 410 testers that we now know how these various lines are connected from a YSNP branch that estimated to be 2,500 years old. Before the L226 SNP pack, our charting was only 40 %, but this robust test includes 40 of the known 44 branches and more than doubled the amount of YSNP data at 20 % the cost of Big Y tests. By the end of this year, charting will be at 90 % and average accuracy will increase by five or ten percent as well.
All we really need is much larger sample sizes (more testers) to be able to connect all the Dal Cais (who are L226) via a chart down surname clusters of related testers. We only have around 40 surname clusters (closely related groups that are dominated by one surname). But there are 200 surnames to sort out.
Obviously, I am a strong advocate for DNA testing - specially the extremely bright future of YDNA testing. Here is the latest genetic descendant chart for L226:
http://www.rcasey.net/DNA/R_L226/Haplotrees/L226_Home.pdf