I've in the past, and when planning, done something similar to your separate sheets, Doddsie, and if I'm on a work in progress / planning, then, as I said, pencil is the thing. I also "do" branches on smaller pads, obviously, if I'm dealing with one branch rather than the overview.
It's very possible IF you make an error, to use a fibreglass eraser, then an indiarubber, then a cowrie shell or similar as a burnisher to make the surface impeccable again - but actually, if you set it out carefully and fully, and adjust at the pencil stage, prior to inking in, there's very little need.
Oddly enough, I tend to start at the foot of the sheet, and work upwards.
I don't think I could get on with "stickers" - but little *s or similar direct the viewer/reader to a panel in a spare space somewhere where extra information can be put.
But I had the impression that the OP (Nookie) was thinking of something more or less complete in itself, and as a visual presentation.
Do give it a go - it really does produce an effective image for display, and, as I said, if you have the skills you can pop a coat of arms ( if you have one - I never have had any in the families) or other decoration in corners.
There's no one perfect way - as Doddsie says, if you are doing branches on different pages the same layout won't do for all - but that's the beauty of the huge sheet and pencil, and having your "minitrees" to hand to help you integrate them into one good layout as you draw them in.
The research for the first/ full one took me years. Assembling the "mini-trees" and planning how/where to place them, and sketching out the main structure took a day or so, off and on. Then drawing it out accurately took an intensive day ( I prefer to work that way).
I then left that for a couple of days, looked at it again, made minor adjustments to the layout, and when I was reasonably happy, got out the pen!
Then I started to "ink in" - if anything a little smaller than I'd written it in the first time. I think this stage was done from the top corner downwards, actually, for practical purposes. I left a margin round and afterwards did some lining in and minor decoration. It did look good, and was easy to follow.
For someone else I did the linking lines in a different colour for each marry-in line, they found that helpful.
It isn't a huge task. Researching and accumulating the evidence is the huge task.
This is the fun bit of the organisation, and how people who are not as fascinated by it all as we are, come to understand what we're doing.
Go on - give it a try. Get that big sheet. Get all your stuff together. I started on the first one by using my main "paternal" line more-or-less as the main trunk, and branching off maternal and marry-in lines as I went up, so it was easy to understand. You can do it.
