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Are you certain that the couple living in Kelsha Co. Wicklow are the same ones that married in Kilkenny city ?

On the baptism for Bridget in 1849 the father's name looks like John to me - plus Patrick's estimated year of birth based on marriage details would work out as being about 1846, so before that marriage in Kilkenny. If that's accurate then maybe he was baptised under his mother's surname or in Kilkenny?

The Lane and Street have separate entries in McCready's Dublin Street Names (1892)

also worth checking Newspapers, the wide street commission placed advertisements relating to each of their projects with notes regarding valuations etc.

are you sure about the street and years?

I eventually located Lord Edward street in directories for 1931 and 1935 on AskaboutIreland website but no sign of Patrick Doherty or a Cycle and Radio shop

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I believe her husband was John Donohue, citied in Tithe Records 1854 in Coolfin, plot no. 6
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I think that should possibly read Griffith's Valuation dated 1856, the Tithe records are much earlier.

There seems to be two townlands named Coolfin in Co. Galway on e in the north past Gort and a second one west of Portumna near the village of Abbey - this one seems to fit the valuation and is in Ballynakill civil parish, Leitrim barony. The Catholic parish would likely be Ballynakill or Woodford both are on the NLI website and can be searched on FindMyPast and Ancestry, the first has baptisms back to 1839, the second back to 1821, neither parish recorded deaths.