Hi
She was married in Wigan, Lancs in 1861.
There was a James Leary (or Lary) living with them on the 1871 England Census in Wigan, who I suspect is Margaret's nephew. He was born in Wigan.
I think his father was also James, born in "Ireland" according to the census abt 1838, who married a Margaret Shean or Shean in Lancashire in 1860.
Regards
SteveK1950