Had a look at this tree on Ancestry - Samuel ISSAC 1709-1781 and Martha AVOKE - 1719-1772
Family Search has a christening at Bristol, 24 December 1754 (Non-Conformist Church Records) of
Ann ISAAC - father: Samuel and mother: Martha
Bristol Records Office holds the Will of Samuel ISAAC, Butcher of St Mary Radcliffe - 1797 - occupation, Butcher.
Checking with National Archives: Held at Bristol - Ancient Lease Corporation of Bristol, Samuel ISAAC, property, Redcliffe - Dr Owen etc - 22 May 1790.
If the ISSAC's are non-conformists family, not sure where Ann would have been buried.
----
Thomas SKEAPING's marriage on Ancestry, notes surname: SCOPINGS or SCEAPINGS and there does appear marriages in Bristol with surname: SKAPING, SCAPENS etc.