Further searching reveals much more, now that I have the Colmworth location. In the monumental inscriptions of Colmworth, I found William and Ann's dates, and also their son William's burial, which mentions 9 children who died in infancy.
Also, there is a 1792 will of William Lugsden mentioning three children of William and Ann Wiles: Elizabeth, James, and William.
johnP: I know you are a Lugsden researcher, but have you any idea of the parents of this William Wiles, husband of Ann Lugsden? I am looking for the William who was born to Thomas Wiles (of Eaton Socon) and Mary Maxey who were married in Great Staughton in 1754. They had an infant William who died in 1757, and then I think there was a second William who may be the one baptised at Southoe in 1760. Unfortunately there are several people named William Wiles living within a short radius of Eaton Socon at the same time and I'm having a hard time differentiating them.